Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ
We report that disruption of the mouse TOP3β gene encoding DNA topoisomerase IIIβ, one of the two mammalian type IA DNA topoisomerases, leads to a progressive reduction in fecundity. The litter size in crosses of top3β(−/−) mice decreases over time and through successive generations, and this decrea...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12591952/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0437998100 |
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