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Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

BACKGROUND: Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is an important strategy for cancer therapy. Here as a proof-of-concept study, we d...

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書誌詳細
出版年:Mol Cancer
主要な著者: Ling, Ling, Tan, Si Kee, Goh, Ting Hwee, Cheung, Edwin, Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511971/
https://ncbi.nlm.nih.gov/pubmed/26201468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0391-4
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