Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway

A new strategy has emerged to improve healing of bone defects using exogenous glycosaminoglycans by increasing the effectiveness of bone-anabolic growth factors. Wnt ligands play an important role in bone formation. However, their functional interactions with heparan sulfate/heparin have only been i...

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Main Authors: Ling, Ling, Dombrowski, Christian, Foong, Kin Mun, Haupt, Larisa M., Stein, Gary S., Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924036/
https://ncbi.nlm.nih.gov/pubmed/20547765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122069
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