Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

BACKGROUND: Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is an important strategy for cancer therapy. Here as a proof-of-concept study, we d...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Ling, Ling, Tan, Si Kee, Goh, Ting Hwee, Cheung, Edwin, Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511971/
https://ncbi.nlm.nih.gov/pubmed/26201468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0391-4
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