Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

BACKGROUND: Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is an important strategy for cancer therapy. Here as a proof-of-concept study, we d...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Ling, Ling, Tan, Si Kee, Goh, Ting Hwee, Cheung, Edwin, Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511971/
https://ncbi.nlm.nih.gov/pubmed/26201468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0391-4
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