Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

BACKGROUND: Aberrant activation of fibroblast growth factor receptors (FGFRs) deregulates cell proliferation and promotes cell survival, and may predispose to tumorigenesis. Therefore, selective inactivation of FGFRs is an important strategy for cancer therapy. Here as a proof-of-concept study, we d...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cancer
Päätekijät: Ling, Ling, Tan, Si Kee, Goh, Ting Hwee, Cheung, Edwin, Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511971/
https://ncbi.nlm.nih.gov/pubmed/26201468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0391-4
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