Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear. We generated mesenchymal progenitor-specific (Runx1(f/f)Twist2-Cre) and osteoblast-specific (Runx1(f/f)Col1α1-Cre) conditional knockout (Runx1 CKO) mice. The mutant CKO mice with normal skeletal development d...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Tang, Chen-Yi, Wu, Mengrui, Zhao, Dongfeng, Edwards, Diep, McVicar, Abigail, Luo, Yuan, Zhu, Guochun, Wang, Yongjun, Zhou, Hou-De, Chen, Wei, Li, Yi-Ping
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819607/
https://ncbi.nlm.nih.gov/pubmed/33476325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009233
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