Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear. We generated mesenchymal progenitor-specific (Runx1(f/f)Twist2-Cre) and osteoblast-specific (Runx1(f/f)Col1α1-Cre) conditional knockout (Runx1 CKO) mice. The mutant CKO mice with normal skeletal development d...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Tang, Chen-Yi, Wu, Mengrui, Zhao, Dongfeng, Edwards, Diep, McVicar, Abigail, Luo, Yuan, Zhu, Guochun, Wang, Yongjun, Zhou, Hou-De, Chen, Wei, Li, Yi-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819607/
https://ncbi.nlm.nih.gov/pubmed/33476325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009233
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