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Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis

One of the fundamental questions in bone biology is where osteoblasts originate and how osteoblast differentiation is regulated. The mechanism underlying which factors regulate chondrocyte to osteoblast lineage commitment remains unknown. Our data showed that Runt-related transcription factor 1 (Run...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Tang, Chen-Yi, Chen, Wei, Luo, Yuan, Wu, Jinjin, Zhang, Yan, McVicar, Abigail, McConnell, Matthew, Liu, Yuehua, Zhou, Hou-De, Li, Yi-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984603/
https://ncbi.nlm.nih.gov/pubmed/32391876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200036
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