Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear. We generated mesenchymal progenitor-specific (Runx1(f/f)Twist2-Cre) and osteoblast-specific (Runx1(f/f)Col1α1-Cre) conditional knockout (Runx1 CKO) mice. The mutant CKO mice with normal skeletal development d...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Tang, Chen-Yi, Wu, Mengrui, Zhao, Dongfeng, Edwards, Diep, McVicar, Abigail, Luo, Yuan, Zhu, Guochun, Wang, Yongjun, Zhou, Hou-De, Chen, Wei, Li, Yi-Ping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819607/
https://ncbi.nlm.nih.gov/pubmed/33476325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009233
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