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Renal cyst growth is the main determinant for hypertension and concentrating deficit in PKD1-deficient mice
We have bred a Pkd1 floxed allele with a nestin-Cre expressing line to generate cystic mice with preserved GFR to address the pathogenesis of complex ADPKD phenotypes. Hypertension affects about 60% of these patients before loss of renal function, leading to significant morbimortality. Cystic mice w...
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| Publicado no: | Kidney Int |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4510986/ https://ncbi.nlm.nih.gov/pubmed/24429399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.501 |
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