Identification of active transcriptional regulatory elements with GRO-seq

Transcriptional regulatory elements (TREs), including enhancers and promoters, determine the transcription levels of associated genes. We have recently shown that global run-on and sequencing (GRO-seq) with enrichment for 5'-capped RNAs reveals active TREs with high accuracy. Here, we demonstra...

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Publié dans:Nat Methods
Auteurs principaux: Danko, Charles G., Hyland, Stephanie L., Core, Leighton J., Martins, Andre L., Waters, Colin T, Lee, Hyung Won, Cheung, Vivian G., Kraus, W. Lee, Lis, John T., Siepel, Adam
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507281/
https://ncbi.nlm.nih.gov/pubmed/25799441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3329
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