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Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells

RNA polymerase II (Pol II) transcribes hundreds of kilobases of DNA, limiting the production of mRNAs and lncRNAs. We used Global Run-on Sequencing (GRO-seq) to measure the rates of transcription by Pol II following gene activation. Elongation rates vary as much as 4-fold at different genomic loci a...

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Bibliografski detalji
Glavni autori: Danko, Charles G., Hah, Nasun, Luo, Xin, Martins, André L., Core, Leighton, Lis, John T., Siepel, Adam, Kraus, W. Lee
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640649/
https://ncbi.nlm.nih.gov/pubmed/23523369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.015
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