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Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing
Transcription regulation occurs frequently through promoter-associated pausing of RNA polymerase II (Pol II). We developed a Precision nuclear Run-On and sequencing assay (PRO-seq) to map the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution. Pol II accumulates imm...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974810/ https://ncbi.nlm.nih.gov/pubmed/23430654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229386 |
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