Llwytho...

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

RNA polymerases are highly regulated molecular machines. We present a method (global run-on sequencing, GRO-seq) that maps the position, amount, and orientation of transcriptionally engaged RNA polymerases genome-wide. In this method, nuclear run-on RNA molecules are subjected to large-scale paralle...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Core, Leighton J., Waterfall, Joshua J., Lis, John T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833333/
https://ncbi.nlm.nih.gov/pubmed/19056941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162228
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