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Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
RNA polymerases are highly regulated molecular machines. We present a method (global run-on sequencing, GRO-seq) that maps the position, amount, and orientation of transcriptionally engaged RNA polymerases genome-wide. In this method, nuclear run-on RNA molecules are subjected to large-scale paralle...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2833333/ https://ncbi.nlm.nih.gov/pubmed/19056941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162228 |
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