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Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing

Transcription regulation occurs frequently through promoter-associated pausing of RNA polymerase II (Pol II). We developed a Precision nuclear Run-On and sequencing assay (PRO-seq) to map the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution. Pol II accumulates imm...

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Bibliografiske detaljer
Main Authors: Kwak, Hojoong, Fuda, Nicholas J., Core, Leighton J., Lis, John T.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974810/
https://ncbi.nlm.nih.gov/pubmed/23430654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229386
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