Elucidating Compound Mechanism of Action by Network Perturbation Analysis

Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds characterizing their targets, effectors, and activity modulators, represents a highly relevant yet elusive goal, with critical implications for assessment of compound efficacy and toxicity. Current approaches are...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Woo, Jung Hoon, Shimoni, Yishai, Yang, Wan Seok, Subramaniam, Prem, Iyer, Archana, Nicoletti, Paola, Martínez, María Rodríguez, López, Gonzalo, Mattioli, Michela, Realubit, Ronald, Karan, Charles, Stockwell, Brent R., Bansal, Mukesh, Califano, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506491/
https://ncbi.nlm.nih.gov/pubmed/26186195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.05.056
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