Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells

Malignant cells drive the generation of a desmoplastic and immunosuppressive tumor microenvironment. Cancer-associated stromal cells (CASCs) are a heterogeneous population that provides both negative and positive signals for tumor cell growth and metastasis. Fibroblast activation protein (FAP) is a...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lo, Albert, Wang, Liang-Chuan S, Scholler, John, Monslow, James, Avery, Diana, Newick, Kheng, O'Brien, Shaun, Evans, Rebecca A., Bajor, David J., Clendenin, Cynthia, Durham, Amy C, Buza, Elizabeth L, Vonderheide, Robert H, June, Carl H, Albelda, Steven M, Puré, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506263/
https://ncbi.nlm.nih.gov/pubmed/25979873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3041
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