TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor binding sites in chronic myelomonocytic leukemia

TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well as other covalently-modified cytosines and its mutations are common in myeloid leukemia. However, the exact mechanism and the extent to which TET2 mutations affect DNA methylation remain in question. Here we report on DN...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Yamazaki, Jumpei, Jelinek, Jaroslav, Lu, Yue, Cesaroni, Matteo, Madzo, Jozef, Neumann, Frank, He, Rong, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R., Kantarjian, Hagop M., Liang, Shoudan, Estecio, Marcos R., Godley, Lucy A., Issa, Jean-Pierre J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506197/
https://ncbi.nlm.nih.gov/pubmed/25972343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0739
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker