A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Genetic changes are infrequent in acute myeloid leukemia (AML) compared to other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot samples selected for cured/not-cured, we found higher...

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Publicado en:Leukemia
Autores principales: Kelly, Andrew D., Kroeger, Heike, Yamazaki, Jumpei, Taby, Rodolphe, Neumann, Frank, Yu, Sijia, Lee, Justin T., Patel, Bela, Li, Yuesheng, He, Rong, Liang, Shoudan, Lu, Yue, Cesaroni, Matteo, Pierce, Sherry A., Kornblau, Steven M., Bueso-Ramos, Carlos E., Ravandi, Farhad, Kantarjian, Hagop M., Jelinek, Jaroslav, Issa, Jean-Pierre J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537054/
https://ncbi.nlm.nih.gov/pubmed/28074068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.12
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