A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Genetic changes are infrequent in acute myeloid leukemia (AML) compared to other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot samples selected for cured/not-cured, we found higher...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leukemia
Prif Awduron: Kelly, Andrew D., Kroeger, Heike, Yamazaki, Jumpei, Taby, Rodolphe, Neumann, Frank, Yu, Sijia, Lee, Justin T., Patel, Bela, Li, Yuesheng, He, Rong, Liang, Shoudan, Lu, Yue, Cesaroni, Matteo, Pierce, Sherry A., Kornblau, Steven M., Bueso-Ramos, Carlos E., Ravandi, Farhad, Kantarjian, Hagop M., Jelinek, Jaroslav, Issa, Jean-Pierre J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537054/
https://ncbi.nlm.nih.gov/pubmed/28074068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.12
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