Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/β-CATENIN SIGNALING PATHWAY

Exposure to lead (Pb) from environmental sources remains an overlooked and serious public health risk. Starting in childhood, Pb in the skeleton can disrupt epiphyseal plate function, constrain the growth of long bones, and prevent attainment of a high peak bone mass, all of which will increase susc...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Beier, Eric E., Sheu, Tzong-jen, Dang, Deborah, Holz, Jonathan D., Ubayawardena, Resika, Babij, Philip, Puzas, J. Edward
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505064/
https://ncbi.nlm.nih.gov/pubmed/25975268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629204
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