Lead Induces an Osteoarthritis-like Phenotype in Articular Chondrocytes through Disruption of TGF-β Signaling

Lead remains a significant environmental toxin, and we believe we may have identified a novel target of lead toxicity in articular chondrocytes. These cells are responsible for the maintenance of joint matrix, and do so under the regulation of TGF-β signaling. As lead is concentrated in articular ca...

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Bibliographische Detailangaben
Hauptverfasser: Holz, Jonathan D., Beier, Eric, Sheu, Tzong-Jen, Ubayawardena, Resika, Wang, Meina, Sampson, Erik R., Rosier, Randy N., Zuscik, Michael, Puzas, J. Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839422/
https://ncbi.nlm.nih.gov/pubmed/22517267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22117
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