Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/β-CATENIN SIGNALING PATHWAY

Exposure to lead (Pb) from environmental sources remains an overlooked and serious public health risk. Starting in childhood, Pb in the skeleton can disrupt epiphyseal plate function, constrain the growth of long bones, and prevent attainment of a high peak bone mass, all of which will increase susc...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Beier, Eric E., Sheu, Tzong-jen, Dang, Deborah, Holz, Jonathan D., Ubayawardena, Resika, Babij, Philip, Puzas, J. Edward
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505064/
https://ncbi.nlm.nih.gov/pubmed/25975268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629204
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