Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

Osteoarthritis (OA) is a degenerative joint disease, and the mechanism of its pathogenesis is poorly understood. Recent human genetic association studies showed that mutations in the Frzb gene predispose patients to OA, suggesting that the Wnt/β-catenin signaling may be the key pathway to the develo...

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Detalhes bibliográficos
Main Authors: Zhu, Mei, Tang, Dezhi, Wu, Qiuqian, Hao, Suyang, Chen, Mo, Xie, Chao, Rosier, Randy N, O'Keefe, Regis J, Zuscik, Michael, Chen, Di
Formato: Artigo
Idioma:Inglês
Publicado em: Amer Soc Bone & Mineral Res. 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640321/
https://ncbi.nlm.nih.gov/pubmed/18767925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080901
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