The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

Human JAK2 tyrosine kinase mediates signaling through numerous cytokine receptors. The JAK2 JH2 domain functions as a negative regulator and is presumed to be a catalytically inactive pseudokinase, but the mechanism(s) for its inhibition of JAK2 remains unknown. Mutations in JH2 lead to increased JA...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Ungureanu, Daniela, Wu, Jinhua, Pekkala, Tuija, Niranjan, Yashavanthi, Young, Clifford, Jensen, Ole N., Xu, Chong-Feng, Neubert, Thomas A., Skoda, Radek C., Hubbard, Stevan R., Silvennoinen, Olli
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504201/
https://ncbi.nlm.nih.gov/pubmed/21841788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2099
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