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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Silvennoinen, Olli, Hubbard, Stevan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447858/
https://ncbi.nlm.nih.gov/pubmed/25824690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-621110
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