Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors

A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Negl Trop Dis
Autori principali: Avelar, Leandro A. A., Camilo, Cristian D., de Albuquerque, Sérgio, Fernandes, William B., Gonçalez, Cristiana, Kenny, Peter W., Leitão, Andrei, McKerrow, James H., Montanari, Carlos A., Orozco, Erika V. Meñaca, Ribeiro, Jean F. R., Rocha, Josmar R., Rosini, Fabiana, Saidel, Marta E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501791/
https://ncbi.nlm.nih.gov/pubmed/26173110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003916
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi