On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Hence, peptidomimetic cruzipain inhibitors having a reactive group (known as warhead) are subject to continuous studies to discover novel antichagasic compounds. He...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RSC Med Chem
Prif Awduron: Bonatto, Vinicius, Batista, Pedro Henrique Jatai, Cianni, Lorenzo, De Vita, Daniela, Silva, Daniel G., Cedron, Rodrigo, Tezuka, Daiane Y., de Albuquerque, Sérgio, Moraes, Carolina Borsoi, Franco, Caio Haddad, Lameira, Jerônimo, Leitão, Andrei, Montanari, Carlos A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: RSC 2020
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126975/
https://ncbi.nlm.nih.gov/pubmed/34095840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00097c
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg