On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Hence, peptidomimetic cruzipain inhibitors having a reactive group (known as warhead) are subject to continuous studies to discover novel antichagasic compounds. He...

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Опубликовано в: :RSC Med Chem
Главные авторы: Bonatto, Vinicius, Batista, Pedro Henrique Jatai, Cianni, Lorenzo, De Vita, Daniela, Silva, Daniel G., Cedron, Rodrigo, Tezuka, Daiane Y., de Albuquerque, Sérgio, Moraes, Carolina Borsoi, Franco, Caio Haddad, Lameira, Jerônimo, Leitão, Andrei, Montanari, Carlos A.
Формат: Artigo
Язык:Inglês
Опубликовано: RSC 2020
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126975/
https://ncbi.nlm.nih.gov/pubmed/34095840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00097c
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