Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors

A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and twelve variations respectively at the P1, P2 and...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:PLoS Negl Trop Dis
Main Authors: Avelar, Leandro A. A., Camilo, Cristian D., de Albuquerque, Sérgio, Fernandes, William B., Gonçalez, Cristiana, Kenny, Peter W., Leitão, Andrei, McKerrow, James H., Montanari, Carlos A., Orozco, Erika V. Meñaca, Ribeiro, Jean F. R., Rocha, Josmar R., Rosini, Fabiana, Saidel, Marta E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501791/
https://ncbi.nlm.nih.gov/pubmed/26173110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003916
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares