Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/S1´ subsites. The same series was evaluated o...

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Bibliografiska uppgifter
I publikationen:PLoS Negl Trop Dis
Huvudupphovsmän: Cianni, Lorenzo, Lemke, Carina, Gilberg, Erik, Feldmann, Christian, Rosini, Fabiana, Rocho, Fernanda dos Reis, Ribeiro, Jean F. R., Tezuka, Daiane Y., Lopes, Carla D., de Albuquerque, Sérgio, Bajorath, Jürgen, Laufer, Stefan, Leitão, Andrei, Gütschow, Michael, Montanari, Carlos A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067379/
https://ncbi.nlm.nih.gov/pubmed/32163418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007755
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