Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Damaged mitochondria are removed by mitophagy. Although Atg32 is essential for mitophagy in yeast, no Atg32 homologue has been identified in mammalian cells. Here, we show that Bcl-2-like protein 13 (Bcl2-L-13) induces mitochondrial fragmentation and mitophagy in mammalian cells. First, we hypothesi...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Murakawa, Tomokazu, Yamaguchi, Osamu, Hashimoto, Ayako, Hikoso, Shungo, Takeda, Toshihiro, Oka, Takafumi, Yasui, Hiroki, Ueda, Hiromichi, Akazawa, Yasuhiro, Nakayama, Hiroyuki, Taneike, Manabu, Misaka, Tomofumi, Omiya, Shigemiki, Shah, Ajay M., Yamamoto, Akitsugu, Nishida, Kazuhiko, Ohsumi, Yoshinori, Okamoto, Koji, Sakata, Yasushi, Otsu, Kinya
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501433/
https://ncbi.nlm.nih.gov/pubmed/26146385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8527
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