Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Damaged mitochondria are removed by mitophagy. Although Atg32 is essential for mitophagy in yeast, no Atg32 homologue has been identified in mammalian cells. Here, we show that Bcl-2-like protein 13 (Bcl2-L-13) induces mitochondrial fragmentation and mitophagy in mammalian cells. First, we hypothesi...

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Publicado no:Nat Commun
Main Authors: Murakawa, Tomokazu, Yamaguchi, Osamu, Hashimoto, Ayako, Hikoso, Shungo, Takeda, Toshihiro, Oka, Takafumi, Yasui, Hiroki, Ueda, Hiromichi, Akazawa, Yasuhiro, Nakayama, Hiroyuki, Taneike, Manabu, Misaka, Tomofumi, Omiya, Shigemiki, Shah, Ajay M., Yamamoto, Akitsugu, Nishida, Kazuhiko, Ohsumi, Yoshinori, Okamoto, Koji, Sakata, Yasushi, Otsu, Kinya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501433/
https://ncbi.nlm.nih.gov/pubmed/26146385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8527
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