Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure. A small chemical, E6446 [(6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole)], is a spec...

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Dettagli Bibliografici
Pubblicato in:JACC Basic Transl Sci
Autori principali: Ueda, Hiromichi, Yamaguchi, Osamu, Taneike, Manabu, Akazawa, Yasuhiro, Wada-Kobayashi, Haruko, Sugihara, Ryuta, Yorifuji, Hiroki, Nakayama, Hiroyuki, Omiya, Shigemiki, Murakawa, Tomokazu, Sakata, Yasushi, Otsu, Kinya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
PRECLINICAL RESEARCH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610159/
https://ncbi.nlm.nih.gov/pubmed/31312759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.01.002
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