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Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology

Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino a...

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Publicat a:J Physiol
Autors principals: Pless, Stephan A, Kim, Robin Y, Ahern, Christopher A, Kurata, Harley T
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500348/
https://ncbi.nlm.nih.gov/pubmed/25640301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.287714
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