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PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels
Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability through the activation of voltage-gated KCNQ2–5 potassium channels. Retigabine binds to the pore-forming domain, causing a hyperpolarizing shift in the voltage dependence of channel activation. To elucidate...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692535/ https://ncbi.nlm.nih.gov/pubmed/29078287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705802114 |
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