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Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation, but the atomic determinants that regulate the kine...

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Autors principals: Pless, Stephan A, Galpin, Jason D, Niciforovic, Ana P, Kurata, Harley T, Ahern, Christopher A
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852034/
https://ncbi.nlm.nih.gov/pubmed/24327560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01289
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