Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

Voltage-gated sodium (Na(V)) channels mediate electrical excitability in animals. Despite strong sequence conservation among the voltage-sensor domains (VSDs) of closely related voltage-gated potassium (K(V)) and Na(V) channels, the functional contributions of individual side chains in Na(v) VSDs re...

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Autores principales: Pless, Stephan A., Elstone, Fisal D., Niciforovic, Ana P., Galpin, Jason D., Yang, Runying, Kurata, Harley T., Ahern, Christopher A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2014
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003186/
https://ncbi.nlm.nih.gov/pubmed/24778431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311036
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