Laddar...
Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity
AIMS: To extend the physiologically based pharmacokinetic (PBPK) model developed for 6-mercaptopurine to account for intracellular metabolism and to explore the role of genetic polymorphism in the TPMT enzyme on the pharmacokinetics of 6-mercaptopurine. METHODS: The developed PBPK model was extended...
Sparad:
| I publikationen: | Br J Clin Pharmacol |
|---|---|
| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
John Wiley & Sons, Ltd
2015
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500328/ https://ncbi.nlm.nih.gov/pubmed/25614061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12588 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|