The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

BACKGROUND: Warfarin is a drug with a narrow therapeutic index and large interindividual variability in daily dosing requirements. Patients commencing warfarin treatment are at risk of bleeding due to excessive anticoagulation caused by overdosing. The interindividual variability in dose requirement...

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Hlavní autoři: Lane, Steven, Al-Zubiedi, Sameh, Hatch, Ellen, Matthews, Ivan, Jorgensen, Andrea L, Deloukas, Panos, Daly, Ann K, Park, B Kevin, Aarons, Leon, Ogungbenro, Kayode, Kamali, Farhad, Hughes, Dyfrig, Pirmohamed, Munir
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2012
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248257/
https://ncbi.nlm.nih.gov/pubmed/21692828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04051.x
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