The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

BACKGROUND: Warfarin is a drug with a narrow therapeutic index and large interindividual variability in daily dosing requirements. Patients commencing warfarin treatment are at risk of bleeding due to excessive anticoagulation caused by overdosing. The interindividual variability in dose requirement...

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Detalhes bibliográficos
Main Authors: Lane, Steven, Al-Zubiedi, Sameh, Hatch, Ellen, Matthews, Ivan, Jorgensen, Andrea L, Deloukas, Panos, Daly, Ann K, Park, B Kevin, Aarons, Leon, Ogungbenro, Kayode, Kamali, Farhad, Hughes, Dyfrig, Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248257/
https://ncbi.nlm.nih.gov/pubmed/21692828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04051.x
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