The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

BACKGROUND: Warfarin is a drug with a narrow therapeutic index and large interindividual variability in daily dosing requirements. Patients commencing warfarin treatment are at risk of bleeding due to excessive anticoagulation caused by overdosing. The interindividual variability in dose requirement...

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Dettagli Bibliografici
Autori principali: Lane, Steven, Al-Zubiedi, Sameh, Hatch, Ellen, Matthews, Ivan, Jorgensen, Andrea L, Deloukas, Panos, Daly, Ann K, Park, B Kevin, Aarons, Leon, Ogungbenro, Kayode, Kamali, Farhad, Hughes, Dyfrig, Pirmohamed, Munir
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2012
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248257/
https://ncbi.nlm.nih.gov/pubmed/21692828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04051.x
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