The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

BACKGROUND: Warfarin is a drug with a narrow therapeutic index and large interindividual variability in daily dosing requirements. Patients commencing warfarin treatment are at risk of bleeding due to excessive anticoagulation caused by overdosing. The interindividual variability in dose requirement...

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Bibliografske podrobnosti
Main Authors: Lane, Steven, Al-Zubiedi, Sameh, Hatch, Ellen, Matthews, Ivan, Jorgensen, Andrea L, Deloukas, Panos, Daly, Ann K, Park, B Kevin, Aarons, Leon, Ogungbenro, Kayode, Kamali, Farhad, Hughes, Dyfrig, Pirmohamed, Munir
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2012
Teme:
Pharmacokinetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248257/
https://ncbi.nlm.nih.gov/pubmed/21692828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04051.x
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