Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

Proper DNA damage response is essential for the maintenance of genome integrity. The E3 ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at sites of DNA damage. In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Peng, Bin, Wang, Jing, Hu, Yuan, Zhao, Hongli, Hou, Wenya, Zhao, Hongchang, Wang, Hailong, Liao, Ji, Xu, Xingzhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499147/
https://ncbi.nlm.nih.gov/pubmed/25999347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv528
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