Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

Proper DNA damage response is essential for the maintenance of genome integrity. The E3 ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at sites of DNA damage. In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1...

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Publicado en:Nucleic Acids Res
Autores principales: Peng, Bin, Wang, Jing, Hu, Yuan, Zhao, Hongli, Hou, Wenya, Zhao, Hongchang, Wang, Hailong, Liao, Ji, Xu, Xingzhi
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499147/
https://ncbi.nlm.nih.gov/pubmed/25999347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv528
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