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Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region
Notch receptors are transmembrane proteins that undergo activating proteolysis in response to ligand stimulation. A negative regulatory region (NRR) maintains receptor quiescence by preventing protease cleavage prior to ligand binding. We report here the X-ray structure of the NRR of autoinhibited h...
Guardat en:
| Publicat a: | Structure |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497832/ https://ncbi.nlm.nih.gov/pubmed/26051713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.05.001 |
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