Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Habets, Roger A. J., Groot, Arjan J., Yahyanejad, Sanaz, Tiyanont, Kittichoat, Blacklow, Stephen C., Vooijs, Marc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505536/
https://ncbi.nlm.nih.gov/pubmed/25918160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643676
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