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Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505536/ https://ncbi.nlm.nih.gov/pubmed/25918160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643676 |
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