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Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505536/ https://ncbi.nlm.nih.gov/pubmed/25918160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643676 |
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