Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

Notch receptors are transmembrane proteins that undergo activating proteolysis in response to ligand stimulation. A negative regulatory region (NRR) maintains receptor quiescence by preventing protease cleavage prior to ligand binding. We report here the X-ray structure of the NRR of autoinhibited h...

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Publicado no:Structure
Main Authors: Xu, Xiang, Choi, Sung Hee, Hu, Tiancen, Tiyanont, Kittichoat, Habets, Roger, Groot, Arjan J., Vooijs, Marc, Aster, Jon C., Chopra, Rajiv, Fryer, Christy, Blacklow, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497832/
https://ncbi.nlm.nih.gov/pubmed/26051713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.05.001
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