Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

Proteolytic resistance of Notch prior to ligand binding depends on the structural integrity of a negative regulatory region (NRR) of the receptor that immediately precedes the transmembrane segment. The NRR includes the 3 Lin12/Notch repeats and the juxtamembrane heterodimerization domain, the regio...

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Detalhes bibliográficos
Main Authors: Gordon, Wendy R., Roy, Monideepa, Vardar-Ulu, Didem, Garfinkel, Megan, Mansour, Marc R., Aster, Jon C., Blacklow, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676092/
https://ncbi.nlm.nih.gov/pubmed/19075186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174748
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