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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
Proteolytic resistance of Notch prior to ligand binding depends on the structural integrity of a negative regulatory region (NRR) of the receptor that immediately precedes the transmembrane segment. The NRR includes the 3 Lin12/Notch repeats and the juxtamembrane heterodimerization domain, the regio...
Uloženo v:
| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676092/ https://ncbi.nlm.nih.gov/pubmed/19075186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-174748 |
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