Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

BACKGROUND: Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the receptor, which contains three highly co...

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Detalhes bibliográficos
Main Authors: Gordon, Wendy R., Vardar-Ulu, Didem, L'Heureux, Sarah, Ashworth, Todd, Malecki, Michael J., Sanchez-Irizarry, Cheryll, McArthur, Debbie G., Histen, Gavin, Mitchell, Jennifer L., Aster, Jon C., Blacklow, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726630/
https://ncbi.nlm.nih.gov/pubmed/19701457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006613
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