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Insights into Notch3 Activation and Inhibition Mediated by Antibodies Directed Against its Negative Regulatory Region
Notch receptors are single-pass transmembrane proteins that regulate development and tissue homeostasis in all metazoan organisms. Prior to ligand-induced signaling, Notch receptors adopt a proteolytic-resistant conformation maintained by a critical interdomain interface within a negative regulatory...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3751422/ https://ncbi.nlm.nih.gov/pubmed/23747483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.025 |
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