載入...
Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...
Na minha lista:
| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2015
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505536/ https://ncbi.nlm.nih.gov/pubmed/25918160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643676 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|